Serrapeptase is used for painful conditions including back pain, osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia, carpal tunnel syndrome, migraine headache, and tension headache.

It is also used for conditions that involve pain and swelling (inflammation) including sinusitis, laryngitis, sore throat, ear infections, swelling after surgery, swelling of a vein with the formation of a blood clot (thrombophlebitis), and inflammatory bowel disease (IBD) including ulcerative colitis and Crohn’s disease.

Some people use serrapeptase for heart disease and “hardening of the arteries” (atherosclerosis). Some supplements combine both nattokinase and serrapeptase to leverage the combined effect.

Caution needs to be taken as it may interact with blood thinners.